Keywords
Abstract
Structure of triazole is one of the most important and widely known heterocycles, which is included in many natural products and drugs. Structure of triazole is a base structural component in a variety of drug groups, such as antimicrobial, anti-inflammatory, antiepileptic, antitumor, antiviral, antihypertensive, antimalarial, local anaesthetics, antitubercular, antidepressants, antioxidants, antidiabetic and etc. Strong and varied activity of triazole and its derivatives had established them as pharmacologically significant chemical structures. Basic heterocyclic rings, present in different drugs are 1,2,3-triazole and 1,2,4-triazole.
Analysis of triazole and its derivatives as potential anti-inflammatory and analgesic drugs was conducted in this study.
It is shown, that 1,2,4 – triazole derivatives are characterized by antiexudative and analgesic activity and absence of ulcerogenic effect. Specific antiexudative activity is associated with inhibition of COX-2, Cav 2.2, Lox-5 and influence on other links of inflammation. Antinonciceptive effect of 1,2,4-triazole derivatives
is usually realized on periferic level and is associated with influence on transformation of arachidonic acid, Cav 2,2 channels. Absense of ulcerogenic effect is associated with predominant influence on COX-2. This indicates prospects of search for new non steroidal anti-inflammatory compounds among 1,2,4 –triazole derivatives.