Rational combination of active substances as one of the methods for drugs creation

Abstract

The aim of the study – to evaluate the possibility of rational combination use of active substances, analogues of natural metabolites, to examine and identify new potential pharmacological targets of their actions.

Combination of drugs is a well-known and widely used method in the creation of drugs. However, some commonly used drugs and nutraceuticals containing oral forms of carnitine, choline, ergoteine, phospholipids, lecithin, etc. may contribute to or enhance the development of cardiovascular pathology and its complications. This review provides data from scientific literature in this regard and raises the question of the need to include relevant data in the Instructions for medical use. In addition, data are provided regarding the possibility of eliminating undesirable effects, for example in the case of arginine as a precursor of nitric oxide, using sulfur-containing acid taurine. The mechanism of the synergistic effect of this combination on the vascular endothelial function and systemic effects in general is revealed, while leveling the possible negative effects of arginine. The conclusion is made about the rationality of this approach when combining substances as a method of creating medicines.