Relevance of pharmacological properties research of phytobalsam «Herbal park», which contains clary sage (Salvia sclarea L.)

Abstract

Now the popularity of herbal medicine is growing rapidly. WHO notes that for about 75 % of patients it is advisable to use herbal preparations. Currently, Ukraine is implementing a drug supply strategy for the population through the introduction of import-substituting herbal preparations, but despite efforts made in this direction the number of new herbal medicines entering the pharmaceutical market remains small.
The aim of the study – to assess the relevance of pharmacological properties research of phytobalsam «Herbal park», which contains clary sage (Salvia sclarea L.), based on the analysis of literary sources and Ukrainian pharmaceutical market overview.
The research has shown that Salvia sclarea L. is widely used in traditional medicine. The chemical composition of clary sage can be classified as follows: essential oils (sclareol), fatty oils (α-linolenic ~54 %), tocols (γ-tocopherol, α-tocopherol), carotenoids (lutein), diterpenes of the abietane type (etiopinone, onaphthoquinone diterpenes, 1-oxoethiopinone, salvipizone, ferruginol, carnosic acid). It has been proven that these substances have antioxidant, anti-inflammatory, analgesic, antimicrobial activities, and abietane type diterpenes exhibit antiproliferative and cytotoxic effects.
Ethanol extract of Salvia sclarea L. exhibits anti-inflammatory activity, while aqueous extract shows activity against α-glucosidase and is able to inhibit tyrosinase. Sclareol in the composition of clary sage has anti-inflammatory, antioxidant, analgesic activity, and the essential oils linalool and linalyl acetate have
activity against L. amazonensis. Etiopinone – diterpene of the abietane type in the composition of sage demonstrates cytotoxic activity against several lines of human tumor cells.
An analysis of the Ukrainian pharmaceutical market was carried out and it was found that clary sage is the part of some drugs registered in Ukraine, and the raw material for their preparation is the aerial part of the plant.
After systematizing the data obtained on the chemical composition of Salvia sclarea and analysis of the pharmaceutical market of Ukraine we can conclude about the relevance of the pharmacological properties study of phytobalsam «Herbal park», one of the components of which is clary sage medicinal plant raw
materials.