Keywords
Abstract
The aim of the study – to analyze the literature data and results of own researches concerning mechanisms of development of endothelial dysfunction at cardiovascular diseases and creation of new metabolitotropic cardio- and endothelioprotectors. There were used bibliosemantical, analytical, logical methods and generalization method. The bibliographic database of biomedical information MEDLINE, EMBASE, Medline (PubMed), Web of Science and Cochrane Central was searched for publications in English that match the keywords of this study: meta bolite-protecting cardioprotectors, endothelioprotective activity, cardioprotective activity, treatment, cardiovascular disease, endothelial dysfunction. The connection between endothelial dysfunction and the development or progression of cardiovascular disease, conditions accompanied by metabolic disorders were discussed. The role of the nitroxydergic system in the molecular mechanisms of endothelial dysfunction was shown. The pharmacological characteristics of known metabolitotropic cardioprotectors – thiotriazoline, mildronate and mexidol are described. The results of experimental studies of a new metabolitotropic endothelioprotector of Angiolin are presented. Thus, further search for cardioprotectors among L-lysine derivatives is expedient. Based on the role of nitroxydergic system in ischemic myocardial injury, virtual screening of nitric oxide traps among L-lysine derivatives may be promising.