Signaling, mediator, effector mechanisms of antiinflammatory action of drugs and biologically active substances of various nature

Abstract

The review summarizes and analyzes current data on the features of the anti-inflammatory action of drugs and biologically active substances (BAS) of various nature.
There were considered individual links of signaling, mediator, effector mechanisms that are associated with the specifics of pro-inflammatory response formation. The authors analyzed the features of traditional signaling pathways: NF-κB (Nuclear factor kappa B) and MAPK (Mitogen-Activated Protein Kinase). The role of inflammatory mediators, substances that initiate and regulate inflammatory reactions are dis
cussed.
Special attention is paid to mechanisms involved in realization of the anti-inflammatory action of drugs and BAS of various nature.
The authors substantiated the directions of search and development of new highly effective and much safer molecules. Such molecules should be targeted for the treatment of complex inflammatory diseases. The combination of multiple molecules with complementary mechanisms of action will open new perspectives in strategies for the clinical management of inflammation and pain.