Keywords
biologically active substances
wound-healing activity
Abstract
Recently, in developed countries of the world, one of the ways to improve the medical process, which promises significant success in preserving the health of the population, is an increasing level of implementation of medical, medical-prophylactic, medical-cosmetic and cosmetic products of plant origin. The aim of the study was a comprehensive research of tansy flowers as a potential raw material with pharmacological activity, the development of a medical and cosmetic product based on these phytocomponents and the determination of its wound-healing activity on a linear cut wound model. The work is devoted to the study of the content of biologically active substances in medicinal plant raw materials – tansy flowers, the development of a medical and cosmetic product with extract of tansy flowers and determining its effect on the regenerative processes of the skin. According to the results of the study, the content of polyphenolic compounds, flavonoids, hydroxycinnamic acids and tannins in samples of tansy flowers was determined. An extract was obtained and the composition of a medical and cosmetic product based on tansy flower extract was technologically substantiated. The regenerative properties of the developed medical and cosmetic product were studied on a linear cut wound model. Analysis of the dynamics of linear wound parameters demonstrated a statistically significant acceleration of healing processes in animals of the experimental group compared to both the control group, that did not receive treatment, and the comparison group, that received the reference drug. In particular, a significant reduction in the length of the wound was established at each stage of observation relative to the initial values, which indicates the ability of the product to intensify reparative processes. The data obtained confirm the prospects of using tansy flower dry extract as an active component for products aimed at stimulating of wound-healing and skin regeneration.
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